TAIL-seq: Genome-wide Determination of Poly(A) Tail Length and 3′ End Modifications
نویسندگان
چکیده
منابع مشابه
Pseudo-Seq: Genome-Wide Detection of Pseudouridine Modifications in RNA.
RNA molecules contain a variety of chemically diverse, posttranscriptionally modified bases. The most abundant modified base found in cellular RNAs, pseudouridine (Ψ), has recently been mapped to hundreds of sites in mRNAs, many of which are dynamically regulated. Though the pseudouridine landscape has been determined in only a few cell types and growth conditions, the enzymes responsible for m...
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During polyadenylation, the multi-functional protein nucleophosmin (NPM1) is deposited onto all cellular mRNAs analysed to date. Premature termination of poly(A) tail synthesis in the presence of cordycepin abrogates deposition of the protein onto the mRNA, indicating natural termination of poly(A) addition is required for NPM1 binding. NPM1 appears to be a bona fide member of the complex invol...
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اتیلن یکی از مواد اولیه پتروشیمی می باشد که در بیشترین مقیاس تولید می شود و طیف گسترد? مشتقات گرفته شده از آن، اهمیت این ماده را چند برابر کرده است. اتیلن معمولأ از طریق کراکینگ حرارتی خوراک های متفاوتی از قبیل اتان، نفتا و گازوئیل تولید می شود. به همراه این ماده با ارزش در طول فرایند کراکینگ مواد دیگری مانند استیلن تشکیل می شوند که سم کاتالیست های واحد پلیمراسیون در نظر گرفته می شوند و باید غل...
Structural cooperativity in histone H3 tail modifications.
Post-translational modifications of histone H3 tails have crucial roles in regulation of cellular processes. There is cross-regulation between the modifications of K4, K9, and K14 residues. The modifications on these residues drastically promote or inhibit each other. In this work, we studied the structural changes of the histone H3 tail originating from the three most important modifications; ...
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Yeast histone mRNAs are polyadenylated, yet factors such as Rrp6p and Trf4p, required for the 3'-end processing of non-polyadenylated RNAs, contribute to the cell cycle regulation of these transcripts. Here, we investigated the role of other known 3'-end processing/transcription termination factors of non-polyadenylated RNA in the biogenesis of histone mRNAs, specifically the Nab3p/Nrd1p/Sen1p ...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2014
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2014.02.007